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For more information, please visit New Enterprise Associates, Inc. (NEA) is a global venture capital firm focused on helping entrepreneurs build transformational businesses across multiple stages, sectors and geographies. Amine Sadok Director Biology
Versant Ventures is a leading healthcare venture capital firm committed to helping exceptional entrepreneurs build the next generation of great companies. Since the firm’s founding in 1999, more than 75 Versant companies have achieved successful acquisitions or IPOs. “With our improved understanding of the broad potential of cereblon and other ubiquitin ligases, there is now an opportunity to eliminate major – and currently undruggable – drivers of solid tumors such as transcription factors and adaptor proteins,” said Markus Warmuth, MD, CEO of Monte Rosa and a venture partner at Versant. For more information, please visit A number of these leads possess novel degradation profiles and have demonstrated in vivo efficacy across several different tumor models.“Using this approach we can potentially design drugs for the hundreds to thousands of proteins with glycine loop degrons,” said Alex Mayweg, PhD, managing director at Versant and Monte Rosa board member.
It provided the first convincing evidence that DNA damage is the basic cause of cancer, laying the foundation for the now universally accepted idea that cancer is a genetic disease. In 2018, Monte Rosa was established in Versant’s Ridgeline laboratories in collaboration with The Institute of Cancer Research (ICR) and Cancer Research UK. “Monte Rosa has built a formidable drug discovery capability and portfolio based on access to unique insights into ubiquitin ligase reprogramming,” said Ali Behbahani, MD, general partner at NEA and Monte Rosa board member. He has joined Monte Rosa Therapeutics from Third Rock Ventures, where he worked as an EIR and played an integral role in the venture capital firm’s formation of new biotech companies. A college of the University of London, it is the UK’s top-ranked academic institution for research quality, and provides postgraduate higher education of international distinction. A college of the University of London, it is the UK’s top-ranked academic institution for research quality, and provides postgraduate higher education of international distinction.
You need JavaScript enabled to view it. New Enterprise Associates, Inc. (NEA) is a global venture capital firm focused on helping entrepreneurs build transformational businesses across multiple stages, sectors and geographies.
By the end of 2020, the chemical library is expected to grow to more than 10,000 structures designed for ubiquitin ligase reprogramming.
The company expects to file one or more IND submissions during 2021. The molecule is undergoing further preclinical development and safety testing. The company has developed … Prior to his role at Third Rock Ventures, Markus spent seven years as the Chief Executive Officer of H3 Biomedicine, a biopharmaceutical company that specializes in the discovery and development of genomics-based precision oncology treatments. In parallel the firm co-invests out of its Canadian strategic fund Versant Voyageurs I and its later-stage biotech opportunity fund Versant Vantage I. With nearly $24 billion in cumulative committed capital since the firm’s founding in 1977, NEA invests in technology and healthcare companies at all stages in a company’s lifecycle, from seed stage through IPO.
For further information about Cancer Research UK's work or to find out how to support the charity, please call 0300 123 1022 or visit
“Unlike protacs, these small molecules can degrade proteins that lack classical drug-binding pockets, which include known drivers of certain forms of cancer and other serious diseases.” Versant is currently investing out of its seventh fund, Versant Venture Capital VII, a $600 million global biotech fund closed in December 2018. The platform includes computational capabilities to predict and model ligase-neosubstrate interactions and quantitative proteomics to obtain protein degradation profiles. Every cell has evolved sophisticated machinery to regulate the expression and function of proteins by degradation.
Today it is a world leader at identifying cancer-related genes, discovering new targeted drugs and developing new high-precision forms of radiotherapy.The ICR is a charity and relies on support from partner organisations, funders and the general public. Dr. Thomä recently published a series of seminal papers revealing mechanistic details of cereblon-mediated protein degradation. The company has developed a platform to rationally design small molecules that reprogram ubiquitin ligases to eliminate disease drivers previously deemed undruggable. One of its portfolio leads, MRT-048, has demonstrated a differentiated degradation profile and promising in vivo activity in several models of resistant breast cancer. Dr. Castle has deep expertise in biomarkers and therapy development using computational immunology, bioinformatics, biotechnology, and genomics.
One of its portfolio leads, MRT-048, has demonstrated a differentiated degradation profile and promising in vivo activity in several models of resistant breast cancer. The firm's long track record of successful investing includes more than 230 portfolio company IPOs and more than 390 mergers and acquisitions.
The firm’s emphasis is on biotechnology companies that are discovering and developing novel therapeutics.
To capture the full potential of its technology platform, Monte Rosa also will explore discovery-stage pharma collaborations.Monte Rosa Therapeutics is a biotechnology company developing small molecules to degrade disease-related proteins.
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